Still, the optimal treatment of chronic pancreatitis pain has been debated for many years, and therefore practice differs. Management of chronic pancreatitis should be in a multidisciplinary approach including radiological, endoscopic and surgical expertise combined with pain management, nutritional, endocrinological and psychological support. duodenal and bile duct stenosis, and progressive loss of endocrine and exocrine function resulting in diabetes and maldigestion. Additional symptoms may develop from extension of the pancreatic inflammation and fibrosis to adjacent organs and vascular structures leading to i.e. Pain is the most frequent and debilitating symptom, and the pattern of pain varies widely between patients, ranging from mild complaints to recurrent attacks or continuous uncontrollable pain. The natural history of chronic pancreatitis patients is unpredictable, symptoms (especially pain) seem not always directly correlated with the morphological changes of the pancreas and its surrounding tissues. Chronic pancreatitis is an inflammatory disease of the pancreas characterized by fibrosis and irreversible morphological changes, with permanent loss of endocrine and exocrine function.
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